COX-2 Information: COX-2 Protein, COX-2 Antibody and COX-2 Gene

COX-2 Protein

COX-2 protein function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. {ECO:0000269|PubMed:16373578, ECO:0000269|PubMed:26859324, ECO:0000269|PubMed:27226593}.

COX-2 protein expression

Induction

By cytokines and mitogens.

COX-2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    604.00
  • Mass (KDa)
    68.00

COX-2 Antibody

There are 1 COX-2 antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 COX-2 antibody for IHC-P. Among all these COX-2 antibodies, there are 1 anti-COX-2 rabbit polyclonal antibodies . All the COX-2 anbodies are produced in house and all are in stock. COX-2 antibody customerized service is available.

COX-2 Gene

PTGS2 gene / cDNA is a protein-coding gene which located on 1q31.1. The PTGS2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.238 organisms have orthologs with human gene PTGS2.