CLEC4A Information: CLEC4A Protein, CLEC4A Antibody and CLEC4A Gene

CLEC4A Gene family

CLEC4A Protein

CLEC4A protein function

C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner (PubMed:27015765). Involved in regulating immune reactivity (PubMed:18258799, PubMed:10438934). Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 (PubMed:18258799, PubMed:20530286). In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (PubMed:18258799). May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:10438934). {ECO:0000269|PubMed:10438934, ECO:0000269|PubMed:18258799, ECO:0000269|PubMed:20530286, ECO:0000269|PubMed:27015765}.; (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases. {ECO:0000269|PubMed:21536857}.

CLEC4A protein expression

Tissue specificity

Expressed preferentially in hematopoietic tissues. Expressed in all circulating Ag-presenting cells such as dendritic cells, myeloid cells, monocytes, macrophages, B-cells and epidermal Langerhans cells (at protein level). Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus.

Induction

TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level) (PubMed:11994513). Expression is decreased in dendritic cells by signals inducing their maturation (e.g. CD40 ligand, TLR9 ligands, LPS, and TNF alpha) (PubMed:10438934, PubMed:18258799). Isoform 2: mRNA expression is up-regulated by agonists of neutrophils CSF2/GM-CSF, IL3/interleukin-3, IL4/interleukin-4 and IL13/interleukin-13 (PubMed:11994513).

CLEC4A protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    237.00
  • Mass (KDa)
    27.00

CLEC4A Antibody

There are 10 CLEC4A antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Det), ELISA(Cap), FCM, IHC-P. There are 6 CLEC4A antibody for ELISA, 1 CLEC4A antibody for ELISA(Det), 1 CLEC4A antibody for ELISA(Cap), 3 CLEC4A antibody for FCM, 1 CLEC4A antibody for IHC-P. Among all these CLEC4A antibodies, there are 6 anti-CLEC4A mouse monoclonal antibodies , 1 anti-CLEC4A rabbit monoclonal antibodies , 3 anti-CLEC4A rabbit polyclonal antibodies . All the CLEC4A anbodies are produced in house and all are in stock. CLEC4A antibody customerized service is available.

CLEC4A Gene

CLEC4A gene / cDNA is a protein-coding gene which located on 12p13.31. The CLEC4A gene is conserved in Rhesus monkey, dog, cow, mouse, and rat.61 organisms have orthologs with human gene CLEC4A.