CDK4 Information: CDK4 Protein, CDK4 Antibody and CDK4 Gene

CDK4 Gene family

CDK4 Protein

CDK4 protein function

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:9003781}.

CDK4 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    303.00
  • Mass (Da)
    33.00

CDK4 Antibody

There are 2 CDK4 antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, ICC/IF, IP, ELISA. There are 2 CDK4 antibody for WB, 2 CDK4 antibody for IHC-P, 2 CDK4 antibody for ICC/IF, 2 CDK4 antibody for IP, 1 CDK4 antibody for ELISA. Among all these CDK4 antibodies, there are 2 anti-CDK4 rabbit polyclonal antibodies . All the CDK4 anbodies are produced in house and all are in stock. CDK4 antibody customerized service is available.

CDK4 Gene

CDK4 gene / cDNA is a protein-coding gene which located on 12q14.1. The CDK4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.171 organisms have orthologs with human gene CDK4.