CD96 Protein Overview: Sequence, Structure, Function and Protein Interaction

CD96 Protein Overview

CD96 reagents

The activation of T cells results in the expression or upregulation of both T cell-specific and nonspecific proteins that are required for proliferation or immune functions. By screening a T-cell cDNA library with a specific polyclonal antiserum, followed by probing additional cDNA libraries, Wang et al. (1992) isolated a cDNA encoding a protein they designated 'T-cell activation, increased late expression,' or TACTILE. Sequence analysis predicted that the 569-amino acid TACTILE protein is a member of the immunoglobulin superfamily. TACTILE contains a signal peptide; an extracellular region with 15 N-linked glycosylation sites and a 132-residue stretch rich in serine, threonine, and proline, a characteristic of domains with extensive O-linked glycosylation; a transmembrane domain; and a 45-amino acid cytoplasmic domain. Immunoprecipitation and immunoblot analyses showed that both recombinant and native TACTILE proteins are expressed as 160-kD proteins under reducing conditions. Northern blot analysis revealed expression of a major 4.4- and a minor 2.4-kb TACTILE transcript in cell lines that also express the TACTILE protein.

CD96 protein name

Recommended name
T-cell surface protein tactile
Alternative name
Cell surface antigen CD96 T cell-activated increased late expression protein CD antigen CD96

CD96 Gene family protein

CD96 Protein Sequence

Species Human CD96 protein
Length 585
Mass (Da) 65634
Sequence Human CD96 protein sequence
Species Mouse CD96 protein
Length 602
Mass (Da) 67133
Sequence Mouse CD96 protein sequence
Species Rat CD96 protein
Length 603
Mass (Da) 67228
Sequence Rat CD96 protein sequence

CD96 Protein Molecular Weight & PI

T-cell surface protein tactile precursor (Cell surface antigen CD96) (T cell-activated increased late expression protein) (CD96 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 22-585 T-cell surface protein tactile.

Molecular weight (Da)


Theoretical pI


CD96 Protein Interaction

Recombinant CD96 Protein Feature

CD96 Protein, Human, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
1. Measured by its ability to bind recombinant mouse PVR in a functional ELISA. 2. Measured by its ability to bind recombinant Human CD155 in a functional ELISA.

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