CD74 Gene Sequence, Family, Fuction and Expression Information

CD74 cDNA / Gene Overview

CD74 gene / cDNA is a protein-coding gene which located on 5q33.1. The CD74 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, and frog.234 organisms have orthologs with human gene CD74.

CD74 cDNA / Gene Function

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

CD74 cDNA / Gene Sequence

LOCUS
LOCUS NM_004355 1506 bp mRNA linear PRI 01-JUL-2018
DEFINITION
Homo sapiens CD74 molecule (CD74), transcript variant 2, mRNA.
ACCESSION
NM_004355
VERSION
NM_004355.3

This sequence information is just for reference only.

CD74 Family & Reagents

Gene family

CD74 Gene family reagents (CD molecules)

Approved Symbol Reagent list
NECTIN2
ADAM17
CD59
PDGFRA
ICOSLG
CLEC12A
CDH5
CD93
SIRPA
PRNP
Approved Symbol Reagent list
FCGR3A
ADAM8
LILRA5
CD33
TNFRSF1B
TFRC
IL9R
NCR2
CD8A
TSPAN7

CD74 cDNA / Gene Alias

  • gamma chain of class II antigens
  • HLA-DR-gamma
  • Ia-associated invariant chain
  • MHC HLA-DR gamma chain

CD74 cDNA / Gene Expression

Broad expression in spleen (RPKM 1835.3), lymph node (RPKM 1421.7) and 24 other tissues