CD74 Gene Sequence, Family, Fuction and Expression Information
CD74 cDNA / Gene Overview
CD74 gene / cDNA is a protein-coding gene which located on 5q33.1. The CD74 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, and frog.234 organisms have orthologs with human gene CD74.
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
CD74 cDNA / Gene Sequence
LOCUS NM_004355 1506 bp mRNA linear PRI 01-JUL-2018
Homo sapiens CD74 molecule (CD74), transcript variant 2, mRNA.
This sequence information is just for reference only.