CD70 Gene Sequence, Family, Fuction and Expression Information

CD70 cDNA / Gene Overview

CD70 gene / cDNA is a protein-coding gene which located on 19p13.3. The CD70 gene is conserved in Rhesus monkey, dog, cow, mouse, and rat.108 organisms have orthologs with human gene CD70.

CD70 cDNA / Gene Function

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

CD70 cDNA / Gene Sequence

LOCUS
LOCUS NM_001252 913 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens CD70 molecule (CD70), transcript variant 1, mRNA.
ACCESSION
NM_001252
VERSION
NM_001252.4

This sequence information is just for reference only.

CD70 Family & Reagents

CD70 Gene family reagents (CD molecules)

Approved Symbol Reagent list
BTLA
MST1R
CLEC10A
TNFSF13B
TLR4
ICAM2
SELE
ITGB1
FGFR3
MS4A1
Approved Symbol Reagent list
IL4R
TFRC
CRTAM
NCR2
SPN
TNFRSF10C
IL6ST
INSR
ANPEP
CDH2

CD70 Gene family reagents (Tumor necrosis factor superfamily)

Approved Symbol Reagent list
CD40LG
LTA
TNF
TNFSF11
TNFSF13
TNFSF14
TNFSF18
TNFSF8
Approved Symbol Reagent list
FASLG
LTB
TNFSF10
TNFSF12
TNFSF13B
TNFSF15
TNFSF4
TNFSF9

CD70 cDNA / Gene Alias

  • CD27L

CD70 cDNA / Gene Expression

Low expression observed in reference dataset