CD46 Information: CD46 Protein, CD46 Antibody and CD46 Gene

CD46 Gene family

CD46 Protein

CD46 protein function

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. {ECO:0000269|PubMed:10843656, ECO:0000269|PubMed:12540904}.; (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.; (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. {ECO:0000269|PubMed:12915534, ECO:0000269|PubMed:14566335, ECO:0000269|PubMed:15047806, ECO:0000269|PubMed:15078926, ECO:0000269|PubMed:15919905, ECO:0000269|PubMed:16254377}.; (Microbial infection) Acts as a receptor for cultured Measles virus. {ECO:0000269|PubMed:10972291}.; (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. {ECO:0000269|PubMed:12663806, ECO:0000269|PubMed:12724329}.; (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).

CD46 protein expression

Tissue specificity

Expressed by all cells except erythrocytes.

CD46 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

CD46 Antibody

There are 7 CD46 antibodies which are validated in multiple tissues with various applications, including ELISA, IHC-P, FCM, ICC/IF, WB, IP. There are 3 CD46 antibody for ELISA, 3 CD46 antibody for IHC-P, 4 CD46 antibody for FCM, 2 CD46 antibody for ICC/IF, 1 CD46 antibody for WB, 1 CD46 antibody for IP. Among all these CD46 antibodies, there are 5 anti-CD46 mouse monoclonal antibodies , 1 anti-CD46 rabbit monoclonal antibodies , 1 anti-CD46 rabbit polyclonal antibodies . All the CD46 anbodies are produced in house and all are in stock. CD46 antibody customerized service is available.

CD46 Gene

CD46 gene / cDNA is a protein-coding gene which located on 1q32.2. The CD46 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.91 organisms have orthologs with human gene CD46.