CD4 Information: CD4 Protein, CD4 Antibody and CD4 Gene

CD4 Gene family

CD4 Protein

CD4 protein function

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. {ECO:0000269|PubMed:16951326, ECO:0000269|PubMed:24942581, ECO:0000269|PubMed:2823150}.; (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607). {ECO:0000269|PubMed:12089508, ECO:0000269|PubMed:16331979, ECO:0000269|PubMed:17346169, ECO:0000269|PubMed:2214026, ECO:0000269|PubMed:7909607, ECO:0000269|PubMed:9641677}.

CD4 protein expression

Tissue specificity

Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.

CD4 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

CD4 Antibody

There are 43 CD4 antibodies which are validated in multiple tissues with various applications, including FCM, ELISA, WB, IHC-P, ICC/IF, IP, ELISA(Det), ELISA(Cap). There are 21 CD4 antibody for FCM, 15 CD4 antibody for ELISA, 4 CD4 antibody for WB, 7 CD4 antibody for IHC-P, 1 CD4 antibody for ICC/IF, 1 CD4 antibody for IP, 1 CD4 antibody for ELISA(Det), 1 CD4 antibody for ELISA(Cap). Among all these CD4 antibodies, there are 21 anti-CD4 mouse monoclonal antibodies , 15 anti-CD4 rabbit monoclonal antibodies , 7 anti-CD4 rabbit polyclonal antibodies . All the CD4 anbodies are produced in house and all are in stock. CD4 antibody customerized service is available.

CD4 Gene

CD4 gene / cDNA is a protein-coding gene which located on 12p13.31. The CD4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.152 organisms have orthologs with human gene CD4.