CD3D Gene Sequence, Family, Fuction and Expression Information
CD3D cDNA / Gene Overview
CD3D gene / cDNA is a protein-coding gene which located on 11q23.3. The CD3D gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.154 organisms have orthologs with human gene CD3D.
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]
CD3D cDNA / Gene Sequence
LOCUS NM_000732 771 bp mRNA linear PRI 23-JUN-2018
Homo sapiens CD3d molecule (CD3D), transcript variant 1, mRNA.
This sequence information is just for reference only.