CD38 Gene Sequence, Family, Fuction and Expression Information

CD38 cDNA / Gene Overview

CD38 gene / cDNA is a protein-coding gene which located on 4p15.32. The CD38 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, and frog.172 organisms have orthologs with human gene CD38.

CD38 cDNA / Gene Function

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

CD38 cDNA / Gene Sequence

LOCUS
LOCUS NM_001775 5694 bp mRNA linear PRI 11-JUN-2018
DEFINITION
Homo sapiens CD38 molecule (CD38), transcript variant 1, mRNA.
ACCESSION
NM_001775
VERSION
NM_001775.3

This sequence information is just for reference only.

CD38 Family & Reagents

Gene family

CD38 Gene family reagents (CD molecules)

Approved Symbol Reagent list
CD34
ADAM8
KLRK1
TNFRSF10B
L1CAM
ENPEP
CD276
LIFR
KIT
FCGR3B
Approved Symbol Reagent list
THBD
CD302
IFNGR1
CD4
KLRD1
CD46
PDCD1LG2
LILRB4
CD84
MCAM

CD38 cDNA / Gene Alias

  • ADP-ribosyl cyclase 1
  • NAD(+) nucleosidase

CD38 cDNA / Gene Expression

Broad expression in lymph node (RPKM 11.2), brain (RPKM 10.3) and 17 other tissues

Recombinant CD38 protein citations

Title
Blocking CD38-driven fratricide among T cells enables effective antitumor activity by CD38-specific chimeric antigen receptor T cells
Year
2019
Author
Gao, Z;Tong, C;Wang, Y;Chen, D;Wu, Z;Han, W;
Journal
J Genet Genomics
Title
Blocking CD38-driven fratricide among T cells enables effective antitumor activity by CD38-specific chimeric antigen receptor T cells
Year
2019
Author
Gao, Z;Tong, C;Wang, Y;Chen, D;Wu, Z;Han, W;
Journal
J Genet Genomics