CD38 Gene Sequence, Family, Fuction and Expression Information
CD38 cDNA / Gene Overview
CD38 gene / cDNA is a protein-coding gene which located on 4p15.32. The CD38 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, and frog.172 organisms have orthologs with human gene CD38.
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
CD38 cDNA / Gene Sequence
LOCUS NM_001775 5694 bp mRNA linear PRI 11-JUN-2018
Homo sapiens CD38 molecule (CD38), transcript variant 1, mRNA.
This sequence information is just for reference only.