CBL Protein Overview: Sequence, Structure, Function and Protein Interaction

CBL Protein Overview

The CBL protein primarily functions as an E3 ubiquitin ligase and acts as a negative regulator of several receptor protein tyrosine kinase signaling pathways by targeting receptors for degradation and as an adaptor protein in tyrosine phosphorylation-dependent signaling (Thien et al., 2001; Fu et al., 2003).

CBL protein name

Recommended name
E3 ubiquitin-protein ligase CBL
Aliases
c-Cbl, oncogene CBL2, RNF55

CBL Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 1-906 E3 ubiquitin-protein ligase CBL.

Molecular weight (Da)

99632.79

Theoretical pI

6.10

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