CBL Information: CBL Protein, CBL Antibody and CBL Gene

CBL Gene family

CBL Protein

CBL protein function

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

CBL protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    906.00
  • Mass (KDa)
    99.00

CBL Antibody

There are 1 CBL antibodies which are validated in multiple tissues with various applications, including IHC-P, ICC/IF. There are 1 CBL antibody for IHC-P, 1 CBL antibody for ICC/IF. Among all these CBL antibodies, there are 1 anti-CBL rabbit polyclonal antibodies . All the CBL anbodies are produced in house and all are in stock. CBL antibody customerized service is available.

CBL Gene

CBL cDNA / gene is a gene with protein product which located on 11q23.3. The CBL gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 235 organisms have orthologs with human gene CBL.