Caspase-7 Protein Overview: Sequence, Structure, Function and Protein Interaction

Caspase-7 Protein Overview

Caspase-7 reagents

Programmed cell death (apoptosis) is associated with the hierarchical activation of a number of cysteine proteinases with cleavage preference after asparagine residues, comprising the caspase family C14 of clan CD (Barrett and Rawlings, 2001). Based on their position within this proteolytic cascade, caspases are subdivided into initiator caspases, which include caspase-8 (601763) and caspase-9 (602234), and executioner caspases, which include caspase-3 (600636, also called CPP32), caspase-6 (601532, also called MCH2), and caspase-7, as well as a third group of caspases involved in cytokine activation, namely, caspase-1 (147678, also called ICE), caspase-4 (602664), and caspase-5 (602665). In apoptosis, the upstream caspases triggered by cofactor-mediated transactivation activate the downstream executioner caspases by limited proteolysis. These executioners, in turn, cleave distinct intracellular proteins involved in promoting the apoptotic phenotype.

Caspase-7 protein family

Belongs to the peptidase C14A family.

Caspase-7 protein name

Recommended name
Caspase-7
Short name
CASP-7
Aliases
CMH-1, ICE-LAP3, MCH3
Alternative name
Apoptotic protease Mch-3 CMH-1 ICE-like apoptotic protease 3 ICE-LAP3) Caspase-7 subunit p20 Caspase-7 subunit p11

Caspase-7 Gene family protein

Caspases

Caspase-7 Protein Sequence

Species Human Caspase-7 protein
Length 303
Mass (Da) 34277
Sequence Human Caspase-7 protein sequence
Species Mouse Caspase-7 protein
Length 303
Mass (Da) 34061
Sequence Mouse Caspase-7 protein sequence
Species
Length
Mass (Da)
Sequence

Caspase-7 Protein Molecular Weight & PI

Caspase-7 precursor (EC 3.4.22.60) (CASP-7) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Contains: Caspase-7 subunit p20; Caspase-7 subunit p11] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 24-198 Caspase-7 subunit p20.

Molecular weight (Da)

19718.69

Theoretical pI

8.87

Caspase-7 Protein Structure

CRYSTAL STRUCTURE OF CASPASE-7 IN COMPLEX WITH ACETYL-ASP-GLU-VAL-ASP-CHO
Deposited
2000-05-19   Released:  2001-05-23
Deposition Author(s)
Wei, Y., Charifson, P.S.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.3500 Å
R-Value Free
0.263
R-Value Work
0.185
1F1J From PDB

Human Caspase-7 protein Secondary structure

Caspase-7 Protein Interaction

Recombinant Caspase-7 Protein Feature

Caspase-7 Protein, Human, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
Please contact us for more information.

Recombinant Caspase-7 protein citations

Title
Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3
Year
2019
Author
Ning, X;Wang, Y;Jing, M;Sha, M;Lv, M;Gao, P;Zhang, R;Huang, X;Feng, JM;Jiang, Z;
Journal
Mol. Cell

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