Calreticulin Protein Overview: Sequence, Structure, Function and Protein Interaction

Calreticulin Protein Overview

Calreticulin reagents

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation (Burns et al., 1994).

Calreticulin protein family

Belongs to the calreticulin family.

Calreticulin protein name

Recommended name
Calreticulin
Aliases
autoantigen Ro, cC1qR, CRT, FLJ26680, RO, Sicca syndrome antigen A (autoantigen Ro; calreticulin), SSA
Alternative name
CRP55 Calregulin Endoplasmic reticulum resident protein 60 ERp60 HACBP grp60

Calreticulin Protein Sequence

Species Human Calreticulin protein
Length 417
Mass (Da) 48142
Sequence Human Calreticulin protein sequence
Species Mouse Calreticulin protein
Length 416
Mass (Da) 47995
Sequence Mouse Calreticulin protein sequence
Species Rat Calreticulin protein
Length 416
Mass (Da) 47995
Sequence Rat Calreticulin protein sequence

Calreticulin Protein Molecular Weight & PI

Calreticulin precursor (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 18-417 Calreticulin.

Molecular weight (Da)

46466.37

Theoretical pI

4.29

Calreticulin Protein Structure

Crystal structure of the globular domain of human calreticulin mutant D71K
Deposited
2016-07-21   Released:  2016-08-31
Deposition Author(s)
Gaboriaud, C., Cioci, G.
Organism(s)
Homo sapiens
Expression System
Escherichia coli 'BL21-Gold(DE3)pLysS AG'
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.3000 Å
R-Value Free
0.247
R-Value Work
0.210
5LK5 From PDB

Human Calreticulin protein Secondary structure

Calreticulin Protein Interaction

Recombinant Calreticulin Protein Feature

Calreticulin Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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