Calreticulin Gene Sequence, Family, Fuction and Expression Information
Calreticulin cDNA / Gene Overview
CALR gene / cDNA is a protein-coding gene which located on 19p13.13. The CALR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.156 organisms have orthologs with human gene CALR.
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
Calreticulin cDNA / Gene Sequence
LOCUS NM_004343 1929 bp mRNA linear PRI 01-JUL-2018
Homo sapiens calreticulin (CALR), mRNA.
This sequence information is just for reference only.
Calreticulin cDNA / Gene Alias
Sicca syndrome antigen A (autoantigen Ro; calreticulin)
Calreticulin cDNA / Gene Expression
Ubiquitous expression in thyroid (RPKM 564.2), placenta (RPKM 291.4) and 24 other tissues