C4B Information: C4B Protein, C4B Antibody and C4B Gene

C4B Gene family

C4B Protein

C4B protein function

Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

C4B protein expression

Tissue specificity

Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland,and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response.

C4B protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

C4B Gene

C4B cDNA / gene is a gene with protein product which located on 6p21.33. The C4B gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.