BTK Protein Overview: Sequence, Structure, Function and Protein Interaction

BTK Protein Overview

BTK is a key regulator of B-cell development. Mutations in the BTK gene result in X-linked agammaglobulinemia (XLA; 300755), an immunodeficiency characterized by failure to produce mature B lymphocytes and associated with a failure of Ig heavy chain rearrangement (Rawlings and Witte, 1994).

BTK protein family

Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

BTK protein name

Recommended name
Tyrosine-protein kinase BTK
ATK, Bruton's tyrosine kinase, PSCTK1, XLA
Alternative name
Agammaglobulinemia tyrosine kinase ATK B-cell progenitor kinase BPK Bruton tyrosine kinase

BTK Protein Sequence

Species Human BTK protein
Length 659
Mass (Da) 76281
Sequence Human BTK protein sequence
Species Mouse BTK protein
Length 659
Mass (Da) 76437
Sequence Mouse BTK protein sequence
Mass (Da)

BTK Protein Molecular Weight & PI

Tyrosine-protein kinase BTK (EC (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 2-659 Tyrosine-protein kinase BTK.

Molecular weight (Da)


Theoretical pI


BTK Protein Structure

Crystal structure of PH domain of Bruton's tyrosine kinase
2007-05-07   Released:  2008-05-13
Deposition Author(s)
Murayama, K., Kato-Murayama, M., Mishima, C., Shirouzu, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Homo sapiens
Expression System
Spodoptera frugiperda
Experimental Data Snapshot
2.5800 Å
R-Value Free
R-Value Work
2Z0P From PDB

Human BTK protein Secondary structure

BTK Protein Interaction

Recombinant BTK Protein Feature

BTK Protein, Human, Recombinant (His Tag)

High Purity
> 85 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
The specific activity was determined to be >50 nmol/min/mg using Poly(Glu,Tyr)4:1 peptide as substrate.

Recombinant BTK protein citations

Chitosan/sulfobutylether-β-cyclodextrin nanoparticles for ibrutinib delivery: a potential nanoformulation of novel kinase inhibitor
Zhao, L;Tang, B;Tang, P;Sun, Q;Suo, Z;Zhang, M;Gan, N;Yang, H;Li, H;
J Pharm Sci
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Bittner, ZA;Liu, X;Dickhoefer, S;Kalbacher, H;Bosch, K;

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