Beta-2 microglobulin Protein

Beta-2 microglobulin Protein Overview

Beta-2 microglobulin reagents

Cunningham et al. (1973) reported the complete amino acid sequence of the beta-2-microglobulin protein. It is a single polypeptide chain with a molecular mass of 11.6 kD that shows homology to immunoglobulins and HLA, suggesting a common evolutionary origin. Suggs et al. (1981) isolated a partial cDNA clone corresponding to the B2M gene. The mature protein is predicted to contain 99 amino acids. Gussow et al. (1987) isolated a full-length clone corresponding to the human B2M gene from a human lymphoblastoid cell cDNA library. The deduced 99-residue protein shows 70% amino acid sequence similarity to the mouse protein.

Beta-2 microglobulin protein family

Belongs to the beta-2-microglobulin family.

Beta-2 microglobulin protein name

Recommended name
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
Alternative name
Beta-2-microglobulin form pI 5.3

Beta-2 microglobulin Protein Sequence

Species Human Beta-2 microglobulin protein
Length 119
Mass (Da) 13715
Sequence Human Beta-2 microglobulin protein sequence
Species Mouse Beta-2 microglobulin protein
Length 119
Mass (Da) 13779
Sequence Mouse Beta-2 microglobulin protein sequence
Species Rat Beta-2 microglobulin protein
Length 119
Mass (Da) 13720
Sequence Rat Beta-2 microglobulin protein sequence

Beta-2 microglobulin Protein Molecular Weight & PI

Beta-2-microglobulin precursor [Contains: Beta-2-microglobulin form pI 5.3]Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 21-119 Beta-2-microglobulin.

Molecular weight (Da)

11731.17

Theoretical pI

6.07

Beta-2 microglobulin Protein Structure

Crystal Structure of the human cytomegalovirus protein US2 bound to the MHC class I molecule HLA-A2/tax
Deposited
2001-05-09   Released:  2001-06-06
Deposition Author(s)
Gewurz, B.E., Gaudet, R., Tortorella, D., Wang, E.W., Ploegh, H.L., Wiley, D.C.
Organism(s)
Homo sapiens, Human T-cell leukemia virus 1, Human cytomegalovirus (strain AD169)
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.2000 Å
R-Value Free
0.240
R-Value Work
0.206
1IM3 From PDB

Human Beta-2 microglobulin protein Secondary structure

Beta-2 microglobulin Protein Interaction

Recombinant Beta-2 microglobulin Protein Feature

Beta-2 microglobulin Protein, Human, Recombinant (His Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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