Alk Gene Sequence, Family, Fuction and Expression Information

Alk cDNA / Gene Overview

ALK cDNA / gene is a gene with protein product which located on 2p23.2-p23.1. The ALK gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog. 210 organisms have orthologs with human gene ALK.

Alk cDNA / Gene Function

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

Alk cDNA / Gene Sequence

LOCUS
D45915 2584 bp mRNA linear PRI 27-DEC-2006
DEFINITION
Homo sapiens mRNA for p80 protein, complete cds.
ACCESSION
D45915
VERSION
D45915.1

This sequence information is just for reference only.

Alk Family & Reagents

Alk Gene family reagents (Receptor Tyrosine Kinases)

Approved Symbol Reagent list
ROR1
MET
FGFR3
MERTK
KIT
INSR
FLT4
DDR2
MUSK
KDR
Approved Symbol Reagent list
FLT1
FGFR2
DDR1
FGFR4
Tie1
PDGFRA
NTRK2
ROR2
RYK
NTRK1

Alk Gene family reagents (CD molecules)

Approved Symbol Reagent list
KLRC1
IL7R
GYPA
CD276
CD200
MUC1
NRP1
MCAM
LY75
CD74
Approved Symbol Reagent list
SIRPG
SDC1
TNFSF13B
TNFRSF11A
CD3E
IGF1R
BCAM
TNFSF13
IL1R2
ICAM4

Alk cDNA / Gene Alias

  • CD246

Alk cDNA / Gene Expression

Low expression observed in reference dataset