Alk Gene Sequence, Family, Fuction and Expression Information
Alk cDNA / Gene Overview
ALK cDNA / gene is a gene with protein product which located on 2p23.2-p23.1. The ALK gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog. 210 organisms have orthologs with human gene ALK.
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
Alk cDNA / Gene Sequence
D45915 2584 bp mRNA linear PRI 27-DEC-2006
Homo sapiens mRNA for p80 protein, complete cds.
This sequence information is just for reference only.