SARS-CoV

What is SARS?

SARS is Severe acute respiratory syndrome,caused by SARS-CoV. SARS can cause more severe respiratory illnesses like pneumonia with symptoms of cough (initially dry), fever, chills, fatigue, myalgia, headache. SARS first emerged in 2002, which caused 8098 people were infected with a case fatality rate of 9.6%. Different from MERS, there is no more cases reported since 2004. At the moment, no specific therapy for SARS-CoV-2, SARS-CoV, MERS-CoV and the other HCoVs infection is available. Symptomatic and supportive treatment is the mainstay of therapy for patients infected by HCoVs.

SARS-CoV

SARS-CoV belongs to Betacornavirus. The genome size of the SARS-CoV varies from 29.0 kb to 30.2 kb which can encodes structural proteins Spike, envelope (E), membrane (M), N proteins and non-structural proteins papain-like protease(s) (PLpro), chymotrypsin-likeprotease (3CLpro), RNA-dependent RNA polymerase (RdRp) and helicase (Hel). Haemagglutinin-esterase gene is absent from the genome of SARS-CoV.

The spike (S) protein is the most important antigen of SARS-CoV. It is composed of two subunits; the S1 subunit contains a receptor-binding domain (RBD) that engages with the host cell receptor angiotensin-converting enzyme 2 (ACE2) and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.
(Ref:Hayes K.H. Luka.Molecular epidemiology, evolution and phylogeny of SARS coronavirus.Infection, Genetics and Evolution.2019)

Cat#   Antigen More
  Nucleocapsid

Expressed Host Insect
Tag His
  S1+S2 ECD (577 S/A)

Expressed Host Insect
Tag His
Binding Activity bind ACE2
  S1 Subunit

Expressed Host Insect
Tag His
  S1 Subunit (Biotinylated)

Expressed Host Insect
Tag His
  S1 Subunit

Expressed Host HEK293
Tag mFc
Binding Activity bind ACE2
  S-RBD

Expressed Host Insect
Tag His
  S-RBD

Expressed Host rFc
Tag His
  S-RBD

Expressed Host HEK293
Tag mFc
Binding Activity bind ACE2
  S2 subunit

Expressed Host Insect
Tag His
  Plpro

Expressed Host E. coli
Tag His
  S-RBD (Biotinylated)

Expressed Host Insect
Tag His
Cat#   Antigen More
  Nucleocapsid

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Mouse MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit PAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
40150-RP01
  Spike

Ab Type Rabbit PAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Rabbit PAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Rabbit MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Nucleocapsid

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Mouse MAb
Application WB, ELISA, IHC-P, FCM, ICC/IF, IP
  Spike

Ab Type Chimeric MAb
Application ELISA
  Nucleocapsid

Ab Type Rabbit MAb
Application ELISA
Recombinant Antibody Production