Structure of Complement Receptors

Complement Receptor Structure Information

Gene ID Description Classification Pdb code 3D Structure
CR1 complement C3b/C4b receptor 1 lipid binding protein 5FO9
CR2 complement C3d receptor 2 immune system 3OED
ITGAM integrin subunit alpha M cell adhesion 4M76
ITGAX integrin subunit alpha X cell adhesion 1N3Y

Complement Receptor Structure References

1. Forneris F, et al. (2016). Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode. The EMBO journal, e201593673.
2. van den Elsen J M, et al. (2011). A crystal structure of the complex between human complement receptor 2 and its ligand C3d. Science, 332(6029), 608-611.
3. Bajic G, et al. (2013). Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3. Proceedings of the National Academy of Sciences, 110(41), 16426-16431.
4. Vorup-Jensen T, et al. (2003). Structure and allosteric regulation of the αXβ2 integrin I domain. Proceedings of the National Academy of Sciences, 100(4), 1873-1878.