What are CD antigens

CD antigens definition

The CD antigens / Cluster of Differentiation nomenclature was established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), which was held in Paris in 1982. The HLDA Workshops provide a mechanism to allocate CD nomenclature through engaging in inter-laboratory studies.Today, the HLDA Workshop meeting has been held 10 times and has over 371 CD markers have been identified.

The CD antigen is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells. CD antibodies are used widely for research, differential diagnosis, monitoring and treatment of disease.

CD antigens expression

CD antigens for cluster of differentiation, which indicates a defined subset of cellular surface receptors (epitopes) that identify cell type and stage of differentiation, and which are recognized by antibodies.

B Cell CD antigens

CD40 is belonging to the TNF receptor superfamily. CD40 is expressed on B cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells and several tumor cell lines. Human and mouse CD40s have 64% identity of amino acid sequence identity.

CD72 is a membrane glycoprotein of the C-type lectin family. CD72 is a pan-B cell marker that is expressed throughout the B lymphocytes differentiation (except plasma cells). CD72 is also present on follicular dendritic cells.

Also: B cells are coated with CD10CD19CD20CD22CD35CD37, and CD45 together with non-CD antigens

T Cell CD antigens

CD4 is an membrane glycoprotein expressed predominantly on T cell , providing the surface protein to which HIV attaches itself in order to invade the cell. CD4 is also found on the surface of monocytes, macrophages, dendritic cells, astrocytes, keratinocytes and glial cells. The number of serum T4 cells is employed to measure the health of the immune system in people infected with HIV.

CD8 is a co-receptor for the T cell receptor (TCR).CD8 is also be found on natural killer cells, cortical thymocytes, and dendritic cells. 

CD58 is also known as lymphocyte function-associated antigen (LFA-3). CD58 is widely expressed on human hematopoietic and non-hematopoietic tissues, leukocytes, erythrocytes, endothelial and epithelial cells, and fibroblasts.

CD Antigens References

Zola H, et al. (2005) CD molecules 2005: human cell differentiation molecules. Blood. 106(9):3123-6.
Woolfson A, et al. (2006) The application of CD antigen proteomics to pharmacogenomics. Pharmacogenomics 7(5):759-71.
Ellmark P, et al. (2008) The applicability of a cluster of differentiation monoclonal antibody microarray to the diagnosis of human disease. Methods Mol Biol. 439:199-209.
Sakamoto K, et al. (2009) Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours. J Laryngol Otol Suppl. (31):58-63.
Sakamoto K, et al. (2009) Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours. J Laryngol Otol Suppl. (31):58-63.
Lal S, et al. (2009) Using antibody arrays to detect microparticles from acute coronary syndrome patients based on cluster of differentiation (CD) antigen expression. Mol Cell Proteomics. 8(4):799-804.