The B7 family protein is present on the antigen-presenting cell surface, and it interacts with the CD28 receptor on the T cell surface. There are two major types of B7 proteins: B7-1/CD80, and B7-2/CD86. This interaction produces a series of downstream signals which promote the target T cell's survival and activation. Blockade of CD28 is effective in stopping T cell activation. T cells can express the surface protein CD152 as well, which can also bind B7. Binding of the B7 on T-cells to CD152 causes inhibition of the activity of T-cells. As a result, the T cell is blocked from receiving the B7 protein signal and is not activated.
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