Human Leukocyte Differentiation Antigen workshop Ⅷ / HLDA8

What is the aims and approaches of HLDA8?

The Human Leukocyte Differentiation Antigen workshop Ⅷ, held in Adelaide, Australia, in December 2004, allocated 95 new CD designations and made radical changes to its aims and future operational strategy in order to maintain its relevance to modern human biology and clinical practice.

HLDA8 adopted the aims and methodology established at previous workshops. The major aims were (1) to assign CD names to molecules for which good-quality antibodies (at least one) and good molecular data are available (generally meaning that the molecule has been cloned); (2) to validate new antibodies against existing CD molecules; (3) to evaluate a "blind panel" of new monoclonal antibodies with a view to identifying new molecules by cluster analysis, following the traditional approach described above; and (4) to provide a forum for discussing and developing scientific understanding and practical applications of leukocyte differentiation molecules, including their ligands.

Which is the yield of new CD antigens in HLDA8?

HLDA8 were added 95 new molecules to the list of CD antigens, shown in new CD antigens list.

The question of whether HLDA has reached the point of diminishing returns is raised after every workshop. However, there is good reason to believe we have so far accounted for just a fraction of the molecules expressed on leukocyte surfaces and the 95 new designations of HLDA8 support that view.

New CD antigens list of HLDA8

New CD Alias Function
CD118 LIFR, gp190 Regulates a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion
CD172b SIRPβ, SIRB1 Immunoglobulin-like cell surface receptor for CD47. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.
CD172g SIRPγ, SIRPB2 Immunoglobulin-like cell surface receptor that mediates cell-cell adhesion on binding with CD47
CD185 CXCR5, BLR1 Homing and cell movement
CD191 CCR1, MIP-1αR, RANTES-R Chemotaxis, adhesion
CD192 CCR2, MCP-1-R Leukocyte chemotaxis and is an HIV co-receptor
CD196 CCR6, BN-1, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22 Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and affects dendritic cell chemotaxis.
CD249 Aminopeptidase AM, EAP, ENPEP Converts angiotensin II to angiotensin III.
CD252 OX40L, gp34 Ligand for receptor TNFRSF4. Co-stimulates T-cell proliferation and cytokine production
CD253 TRAIL, Apo-2L, TL2, TNFSF10 Induces cell death by apoptosis
CD254 TNFSF11, RANKL, OPGL, ODF Involved in dendritic cell maturation
CD256 APRIL, TALL-2, TRDL-1, TNFSF13 Important for B cell development
CD257 BLyS, BAFF, TALL-1, TNFSF13B Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity
CD258 LIGHT, HVEM-L, TNFRSF14 Stimulates T-cell proliferation, receptor for Herpes simplex virus
CD261 TRAIL-R1, DR4, TNFRSF10A Induces apoptosis, promotes activation of NFkB
CD262 TRAIL-R2, DR5, TNFRSF10B Activated by TNFSF10 / TRAIL and transduces apoptosis signal
CD264 DCR2, TRAIL-R4, TNFRSF10D Receptor for TRAIL, inhibits apoptosis
CD265 RANK, TRANCE-R, ODFR, TNFRSF11A Receptor for TRANCE. Enhances T-cell growth and dendritic cell function, plays a role in lymph node organogenesis
CD266 TWEAK-R, FGF-inducible 14, TNFRSF12A Receptor for TWEAK. Promotes angiogenesis and the proliferation of endothelial cells.
CD267 TACI, TNFR SF13B, TNFRSF13B Receptor for CD256 and CD257, mediates activation of the transcription factors NFAT, AP1, and NFkB.
CD268 BAFFR, TR13C,TNFRSF13C B-cell receptor for CD257. B-cell response
CD269 BCMA, TNFRSF13B, TNFRSF17 Receptor for CD256 and CD257, activates NFkB and JNK.
CD271 NGFR, p75 (NTR) Regulates neuronal growth, migration, differentiation and cell death during stem cells.
CD272 BTLA Lymphocyte inhibitory receptor
CD273 B7DC, PD-L2, PDCD1L2 Stimulatory on dendritic cells, inhibits T-cell activation upon engaging the PD1 receptor.
CD274 B7-H1, PD-L1 Found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition
CD275 B7-H2, ICOSL, B7-RP1, GL50 Ligand for CD278. Costimulatory signal for T-cell proliferation and cytokine secretion, induces B-cell proliferation and differentiation
CD276 B7-H3 Enhances the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling
CD277 BTN3A1, butyrophilin SF3 A1, BTF5 T-cell activation
CD278 ICOS, AILIM Mediate cell-cell interactions, and effective help for antibody secretion by B-cells
CD279 PD1, SLEB2 Inhibitory cell surface receptor involved in T-cell tolerance
CD281 TLR1 Pathogen recognition and activation of innate immunity, regulates TLR2 function
CD282 TLR2 Mediator of innate immunity against bacterial cell wall lipoproteins. Induces activation of NFkB
CD283 TLR3 Mediator of innate immunity against viral infection, activated by dsDNA
CD284 TLR4 Mediator to innate immunity against bacterial polysaccharides. Induces activation of NFkB and production of type I interferons
CD292 BMPR1A, ALK3, SKR5 Receptor for BMP-2 and BMP-4
CD295 LeptinR, LEPR, OB-R, Leptin Receptor Receptor for leptin. Involved in the regulation of fat metabolism and required for normal lymphopoiesis
CD296 ART1, ARTC1 Catalyzes the transfer of ADP-ribose from NAD+ to arginine residues in proteins
CD297 ART4, dombrock blood group Plays a role in the metabolism of Dombrock blood group antigen
CD298 ATP1B3, ATPB-3 Component of Na+-K+ pump on neuronal membranes.
CD299 DC-SIGN-related, LSIGN, DC-SIGN2, CLEC4M, DC-SIGNR Pathogen-recognition receptor involved in peripheral immune surveillance in liver. Recognizes mannose N-linked oligosaccharides in HIV-1, HIV-2, human cytomegalovirus and human SARS coronavirus
CD300a CMRF35H, IRC1, IRp60M, CLM-8 NK cell function; also suppresses the effects of eotaxin, IL-5 and GM-CSF on neutrophils; and inhibits Ig-E dependent
CD300c CMRF35A, LIR, CLM-6 Regulates IFN-alpha and TNF-alpha secretion by plasmacytoid dendritic cells
CD300e CMRF35L, CLM-2, CMRF35-A5 Prevents apoptosis, triggers the production of pro-inflammatory cytokines and upregulates the expression of cell surface co-stimulatory molecules
CD301 MGL, HML, CLEC10A, MGL1 Cell adhesion, cell-cell signaling and cellular recognition through glycoprotein binding
CD302 DCL1, BIMLEC Cell adhesion and migration
CD304 BDCA4, neuropilin 1, CLEC4C, NRP1 Angiogensis, axon guidance, cell survival, migration, and invasion
CD305 LAIR1 Negative regulator of NK, B, and T cells
CD306 LAIR2 Inhibits cellular activation and inflammation
CD307 IRTA2, FCRL5 May function in B-cells activation and differentiation
CD309 VEGFR2, KDR, FLK-1 Activation of this receptor by VEGF plays a role in angiogenesis, development, wound healing, cell proliferation, migration and differentiation
CD314 NKG2D, KLRK1 Receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells
CD315 PTGFRN, CD9P-1, EWI-F, FPRP, SMAP-6 Inhibits binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor.
CD316 EWI2, PGRL, CD81P3, KASP,IGSF8, EWI-2, KCT-4 Negative regulator of cell motility.
CD317 BST2, HM1.24 IFN-induced antiviral host restriction factor
CD318 CDCP1, SIMA135 Cell differentiation, homing and dissemination. May also have a pro-survival role
CD319 CRACC, SLAMF7 Mediates NK cell activation and may play a role in lymphocyte adhesion
CD320 FDC-SM-8D6, TCbIR, 8D6 antigen Augments the proliferation of plasma cell precursors generated by IL10. Receptor for the cellular uptake of transcobalamin bound cobalamin
CD321 JAM-A, JAM-1, PAM-1, F11R Plays a role in epithelial tight junction formation, regulation of leukocyte erythrocytes. migration, epithelial barrier maintenance and platelet activation
CD322 JAM-B, JAM-2, VE-JAM May play a role in lymphocyte homing to secondary lymphoid organs
CD324 E-Cadherin, Uvomorulin, CDH1, E-cad Calcium-dependent cell adhesion protein
CD326 Ep-CAM, Ly74, EGP314, TROP-1, TACSTD1 A homotypic calcium-independent T-cell adhesion molecule
CD331 FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM Receptor for basic fibroblast growth factor.
CD332 FGFR2, BEK, KGFR Cell-surface receptor for fibroblast growth factors
CD333 FGFR3, ACH, CEK2 Cell-surface receptor for fibroblast growth factors
CD334 FGFR4, JTK2, TKF Cell-surface receptor for fibroblast growth factors
CD336 NKp44, Ly-95 homolog, NCR2 Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis
CD337 NKp30, Ly117, NCR3 Cytotoxicity-activating receptor that contributes to the increased efficiency ofactivated NK cells to mediate tumor cell lysis
CD339 Jagged-1, JAG1, JAGL1, hJ1 Ligand for multiple Notch receptors. Involved in the mediation of Notch signaling, cell fate determination in hematopoiesis and cardiovascular development