| CD85j Gene ID | 10859 |
| CD85j Official Full Name | leukocyte immunoglobulin like receptor B1 |
| CD85j Alias | LILRB1, ILT2, LIR1 |
| CD85j Cellular Expression | T; B; NK; Dendritic; Macrophage; monocytes |
| CD85j Ligand/Receptor/Association | |
| CD85j Function | Inhibits cytotoxicity in NK and T cells upon ligand binding |
| CD85j Summary | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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