| CD62L Gene ID | 6402 |
| CD62L Official Full Name | selectin L |
| CD62L Alias | L-selectin, LECAM-1, SELL |
| CD62L Cellular Expression | T; B; NK; Granulocyte; Macrophage; monocytes |
| CD62L Ligand/Receptor/Association | CD34, MAdCAM-1, GlyCAM-1, CD57, CD15su |
| CD62L Function | Leukocyte rolling and homing on activated endothelium |
| CD62L Summary | This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] |
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