| CD41 Gene ID | 3674 |
| CD41 Official Full Name | integrin subunit alpha 2b |
| CD41 Alias | ITGA2B, GP2B, HPA3, CD41B, GPIIb, BDPLT2, BDPLT16, PPP1R93 |
| CD41 Cellular Expression | T; B |
| CD41 Ligand/Receptor/Association | fibrinogen, fibronectin, vWF and thrombospondin |
| CD41 Function | cell adhesion, cell-cell signalling |
| CD41 Summary | This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016] |
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