CD331 antigens

CD331 antigens general information

CD331 Gene ID 2260
CD331 Official Full Name fibroblast growth factor receptor 1
CD331 Alias FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM
CD331 Cellular Expression Endothelial; Epithelial
CD331 Ligand/Receptor/Association aFGF, bFGF, K-FGF
CD331 Function Receptor for basic fibroblast growth factor.
CD331 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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