CD32b antigens

CD32b antigens general information

CD32b Gene ID 14130
CD32b Official Full Name Fc receptor, IgG, low affinity IIb
CD32b Alias FcγRII, FCGR2B,Fc gamma RIIB
CD32b Cellular Expression T; B; Endothelial; Granulocyte; Macrophage; Platelet
CD32b Ligand/Receptor/Association  
CD32b Function Phagocytosis of immune complexes and regulation of antibody production
CD32b Summary This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Information from NCBI or Wiki

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