CD322 antigens

CD322 antigens general information

CD322 Gene ID 67374
CD322 Official Full Name junction adhesion molecule 2
CD322 Alias JAM-B, JAM-2, VE-JAM
CD322 Cellular Expression Endothelial
CD322 Ligand/Receptor/Association PAR-3, a4b1 integrin, JAM3, JAM-2
CD322 Function May play a role in lymphocyte homing to secondary lymphoid organs
CD322 Summary CD322 / cluster of differentiation 322 as known as Junctional adhesion molecule B, is a protein that in humans is encoded by the JAM2 gene. CD322 represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

Information from NCBI or Wiki

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