| CD304 Gene ID | 8829 |
| CD304 Official Full Name | neuropilin 1 |
| CD304 Alias | BDCA4, neuropilin 1, CLEC4C, NRP1 |
| CD304 Cellular Expression | T; Dendritic; Endothelial |
| CD304 Ligand/Receptor/Association | VEGF165, SEMA3A, complexed with plexin-1 |
| CD304 Function | Angiogensis, axon guidance, cell survival, migration, and invasion |
| CD304 Summary | This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011] |
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