CD258 antigens

CD258 antigens general information

CD258 Gene ID 8740
CD258 Official Full Name tumor necrosis factor superfamily member 14
CD258 Alias LIGHT, HVEM-L, TNFRSF14
CD258 Cellular Expression T; B; Dendritic; Granulocyte; Macrophage; monocytes
CD258 Ligand/Receptor/Association HVEM, LTβR
CD258 Function Stimulates T-cell proliferation, receptor for Herpes simplex virus
CD258 Summary The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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