CD242 antigens

CD242 antigens general information

CD242 Gene ID 3386
CD242 Official Full Name intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
CD242 Alias ICAM-4
CD242 Cellular Expression Endothelial; Erythrocyte; Stem cell
CD242 Ligand/Receptor/Association CD11a, b; CD18; CD49b, d, e, CD51
CD242 Function Ligand for the leukocyte adhesion protein LFA-1
CD242 Summary This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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