CD221 antigens

CD221 antigens general information

CD221 Gene ID 3480
CD221 Official Full Name insulin like growth factor 1 receptor
CD221 Alias IGF-1 R, IGF1R
CD221 Cellular Expression T; B; NK; Dendritic; Endothelial; Epithelial; Granulocyte; Macrophage; Stem cell
CD221 Ligand/Receptor/Association insulin, IGF-I, IGF-II
CD221 Function Receptor for IGF-I and IGF-II. Mediates mitogenic and anti-apoptotic signals
CD221 Summary This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Information from NCBI or Wiki

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