CD22 antigens

CD22 antigens general information

CD22 Gene ID 12483
CD22 Official Full Name CD22 antigen
CD22 Alias BL-CAM, Siglec-2, Leu-14
CD22 Cellular Expression B; Stem cell
CD22 Ligand/Receptor/Association CD22, IgM, CD45RO, sialoglyco-conjugate NeuGcα2-6Galβ1-4GlcNAc, CD75
CD22 Function B-cell adhesion and signal transduction
CD22 Summary CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.[1] It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.[2] CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.[3] An immunotoxin, BL22, that targets this receptor is being tested at the NIH.[4]

Information from NCBI or Wiki

Tips: We list all the CD antigens according to the specific name of CD molecules.