CD195 antigens

CD195 antigens general information

CD195 Gene ID 1234
CD195 Official Full Name C-C motif chemokine receptor 5
CD195 Alias CCR5, CKR5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5
CD195 Cellular Expression T; Dendritic; Epithelial
CD195 Ligand/Receptor/Association HIV-1, CCL3, CCL4, CCL5
CD195 Function The CCR5 protein belongs to the beta chemokine receptors family of integral membrane proteins.[7][8] It is a G protein–coupled receptor[7] which functions as a chemokine receptor in the CC chemokine group.
CD195 Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]

Information from NCBI or Wiki

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