CD191 antigens

CD191 antigens general information

CD191 Gene ID 12768
CD191 Official Full Name chemokine (C-C motif) receptor 1
CD191 Alias CCR1, MIP-1αR, RANTES-R
CD191 Cellular Expression T; Dendritic; Macrophage; monocytes; Stem cell
CD191 Ligand/Receptor/Association CCL3, 5, 7, 8, 14, 15, 23
CD191 Function Chemotaxis, adhesion
CD191 Summary This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.[2]

Information from NCBI or Wiki

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