CD184 antigens

CD184 antigens general information

CD184 Gene ID 7852
CD184 Official Full Name C-X-C motif chemokine receptor 4
CD184 Alias CXCR4, FB22, HM89, LAP3, LCR1, NPYR, WHIM, LAP-3, LESTR, NPY3R, NPYRL, WHIMS, HSY3RR, NPYY3R, D2S201E
CD184 Cellular Expression T; B; NK; Dendritic; monocytes; Endothelial; Erythrocyte
CD184 Ligand/Receptor/Association HIV-1, SDF-1(CXCL12)
CD184 Function CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells. CD184 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes.
CD184 Summary This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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