| CD184 Gene ID | 7852 |
| CD184 Official Full Name | C-X-C motif chemokine receptor 4 |
| CD184 Alias | CXCR4, FB22, HM89, LAP3, LCR1, NPYR, WHIM, LAP-3, LESTR, NPY3R, NPYRL, WHIMS, HSY3RR, NPYY3R, D2S201E |
| CD184 Cellular Expression | T; B; NK; Dendritic; monocytes; Endothelial; Erythrocyte |
| CD184 Ligand/Receptor/Association | HIV-1, SDF-1(CXCL12) |
| CD184 Function | CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells. CD184 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. |
| CD184 Summary | This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
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