CD158b2 antigens

CD158b2 antigens general information

CD158b2 Gene ID 3804
CD158b2 Official Full Name killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
CD158b2 Alias NKAT-2, KIR2DL3
CD158b2 Cellular Expression T; NK
CD158b2 Ligand/Receptor/Association HLA-Cw1, Cw3, Cw7, Cw8
CD158b2 Function Inhibits the activity of NK cells
CD158b2 Summary Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

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