| CD156a Gene ID | 101 |
| CD156a Official Full Name | ADAM metallopeptidase domain 8 |
| CD156a Alias | ADAM8 |
| CD156a Cellular Expression | Granulocyte; Macrophage; monocytes |
| CD156a Ligand/Receptor/Association | α9β1 integrin |
| CD156a Function | Possible involvement in extravasation of leukocytes |
| CD156a Summary | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Information from NCBI or Wiki
