CD140b antigens

CD140b antigens general information

CD140b Gene ID 5159
CD140b Official Full Name platelet derived growth factor receptor beta
CD140b Alias PDGFRβ, PDGFRB
CD140b Cellular Expression Endothelial; Platelet
CD140b Ligand/Receptor/Association PDGF-B, PDGF-D
CD140b Function Cell proliferation, differentiation and survival
CD140b Summary This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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