CD121b antigens

CD121b antigens general information

CD121b Gene ID 7850
CD121b Official Full Name interleukin 1 receptor type 2
CD121b Alias IL-1R, type II, IL1R2, IL-1R2
CD121b Cellular Expression T; B; Macrophage; monocytes
CD121b Ligand/Receptor/Association IL-1α, IL-1β, IL-1RA
CD121b Function Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling
CD121b Summary The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]

Information from NCBI or Wiki

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