CD114 antigens

CD114 antigens general information

CD114 Gene ID 1441
CD114 Official Full Name colony stimulating factor 3 receptor
CD114 Alias GCSFR, CSF3R
CD114 Cellular Expression Endothelial; Granulocyte; Macrophage; Platelet; Stem cell
CD114 Ligand/Receptor/Association G-CSF
CD114 Function Myeloid cell proliferation and differentiation
CD114 Summary The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene.[1] G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).[2] The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family.The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.

Information from NCBI or Wiki

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