CD105 antigens

CD105 antigens general information

CD105 Gene ID 2022
CD105 Official Full Name endoglin
CD105 Alias Endoglin, ENG, END
CD105 Cellular Expression Endothelial; Macrophage; monocytes; Stem cell
CD105 Ligand/Receptor/Association TGF-β1, TGF-β3
CD105 Function Angiogenesis. Regulatory component of TGF-beta receptor complex.Modulates cellular response to TGF beta 1
CD105 Summary This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Information from NCBI or Wiki

Tips: We list all the CD antigens according to the specific name of CD molecules.