CEACAM1 Protein, Mouse, Recombinant (His Tag)

CEACAM1 Protein, Mouse, Recombinant (His Tag): 製品情報

純度
> 95 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
活性
Testing in progress
タンパク質の構築
A DNA sequence encoding the extracellular domain of mouse CEACAM1 (NP_001034274.1) (Met 1-Gly 428) was expressed, with a polyhistidine tag at the C-terminus.
発現ホスト
HEK293 Cells
Mouse
予測N末端
Glu 35
分子量
The recombinant mouse CEACAM1 consists of 405 amino acids and has a predicted molecular mass of 45 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCEACAM1 is approximately 70-100 kDa due to high glycosylation.
バッファー
Lyophilized from sterile PBS, pH 7.4
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CEACAM1 Protein, Mouse, Recombinant (His Tag): 画像

CEACAM1 Protein, Mouse, Recombinant (His Tag): 別名

bb-1 Protein, Mouse; Bgp Protein, Mouse; Bgp1 Protein, Mouse; C-CAM Protein, Mouse; Cc1 Protein, Mouse; CD66a Protein, Mouse; Cea-1 Protein, Mouse; Cea-7 Protein, Mouse; Cea1 Protein, Mouse; Cea7 Protein, Mouse; Hv-2 Protein, Mouse; Hv2 Protein, Mouse; mCEA1 Protein, Mouse; Mhv-1 Protein, Mouse; MHVR Protein, Mouse; MHVR1 Protein, Mouse; mmCGM1 Protein, Mouse; mmCGM1a Protein, Mouse; mmCGM2 Protein, Mouse

CEACAM1 背景情報

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
完全な名称
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
参考文献
  • Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46.
  • Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82.
  • Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.
  • Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells
    Author
    Klaile, E;Müller, MM;Schäfer, MR;Clauder, AK;Feer, S;Heyl, KA;Stock, M;Klassert, TE;Zipfel, PF;Singer, BB;Slevogt, H;
    Year
    2017
    Journal
    MBio
    Application
    binding
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