CEACAM1 Protein, Mouse, Recombinant (ECD, hFc Tag)

CEACAM1 Protein, Mouse, Recombinant (ECD, hFc Tag): 製品情報

> 85 % as determined by SDS-PAGE
< 1.0 EU per μg protein as determined by the LAL method.
Testing in progress
A DNA sequence encoding the mouse Ceacam1 (NP_001034274.1) (Met1-Gly428) was expressed with the Fc region of human IgG1 at the C-terminus.
HEK293 Cells
Glu 35
The recombinant mouse Ceacam1 consists 632 amino acids and predicts a molecular mass of 70.3 kDa.
Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CEACAM1 Protein, Mouse, Recombinant (ECD, hFc Tag): 画像

CEACAM1 Protein, Mouse, Recombinant (ECD, hFc Tag): 別名

bb-1 Protein, Mouse; Bgp Protein, Mouse; Bgp1 Protein, Mouse; C-CAM Protein, Mouse; Cc1 Protein, Mouse; CD66a Protein, Mouse; Cea-1 Protein, Mouse; Cea-7 Protein, Mouse; Cea1 Protein, Mouse; Cea7 Protein, Mouse; Hv-2 Protein, Mouse; Hv2 Protein, Mouse; mCEA1 Protein, Mouse; Mhv-1 Protein, Mouse; MHVR Protein, Mouse; MHVR1 Protein, Mouse; mmCGM1 Protein, Mouse; mmCGM1a Protein, Mouse; mmCGM2 Protein, Mouse

CEACAM1 背景情報

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
  • Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46.
  • Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82.
  • Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.
  • Fusobacterium spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF
    Brewer, M;Dymock, D;Brady, R;Singer, B;Virji, M;Hill, D;
    Journal of Oral Microbiology
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