MERS-CoV Nucleocapsid Protein (His Tag)

MERS-CoV Nucleocapsid Protein (His Tag): 製品情報

> 90 % as determined by SDS-PAGE
< 1.0 EU per μg of the protein as determined by the LAL method
Testing in progress
A DNA sequence encoding the MERS-CoV Nucleoprotein (AFS88943.1) (Met1-Asp413) was fused with a polyhistidine tag at the C-terminus.
NP No.
Baculovirus-Insect Cells
Met 1
The recombinant Nucleoprotein MERS-CoV comprises 424 amino acids and has a predicted molecular mass of 46.51 kDa.
Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% gly, pH 8.0.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

MERS-CoV Nucleocapsid Protein (His Tag): 画像

MERS-CoV Nucleocapsid Protein (His Tag): 別名

coronavirus NP Protein, MERS-CoV; coronavirus Nucleocapsid Protein, MERS-CoV; coronavirus Nucleoprotein Protein, MERS-CoV; cov np Protein, MERS-CoV; ncov NP Protein, MERS-CoV; novel coronavirus Nucleoprotein Protein, MERS-CoV; NP Protein, MERS-CoV; Nucleocapsid Protein, MERS-CoV; Nucleoprotein Protein, MERS-CoV

Coronavirus Nucleocapsid 背景情報

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. The coronavirus N protein is required for coronavirus RNA synthesis and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is the most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to the formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of the N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
    1. 1.Van Boheemen S, et al. (2012), MBio. 3(6):e00473-12.
    2. Bisht H. et al., 2004, Proc Natl Acad Sci. 101 (17): 6641-6.
    3. Li W. et al., 2005, Science. 309 (5742): 1864-8.

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