PSMA Protein, Human, Recombinant (ECD, His Tag)

PSMA Protein, Human, Recombinant (ECD, His Tag): 製品情報

純度
> 95 % as determined by SDS-PAGE.
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
活性
Testing in progress
タンパク質の構築
A DNA sequence encoding the human FOLH1 (NP_004467.1) (Lys44-Ala750) was expressed with a polyhistidine tag at the N-terminus.
NP No.
発現ホスト
HEK293 Cells
Human
予測N末端
His
分子量
The recombinant human FOLH1 consists 726 amino acids and predicts a molecular mass of 81.86 kDa. As a result of glycosylation, it migrates as an approximately 98.67 KDa band in SDS-PAGE under reducing conditions.
バッファー
Lyophilized from sterile 0.9 mM CaCl2, 0.5 mM MgCl2-6H2O, 2.7 mM KCl, 1.5 mM KH2PO4, 137.9 mM NaCl, 8.1 mM Na2HPO4-7H2O, 0.5 mM ZnCl2, pH 7.2.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PSMA Protein, Human, Recombinant (ECD, His Tag): 画像

PSMA Protein, Human, Recombinant (ECD, His Tag): 別名

FGCP Protein, Human; FOLH Protein, Human; GCP2 Protein, Human; GCPII Protein, Human; mGCP Protein, Human; NAALAD1 Protein, Human; NAALAdase Protein, Human; PSM Protein, Human; PSMA Protein, Human

PSMA 背景情報

Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain (at protein level), and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.
完全な名称
folate hydrolase (prostate-specific membrane antigen) 1
参考文献
  • Israeli R.S., et al.,(1993), Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res. 53:227-230.
  • Su S.L., et al., (1995), Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression.Cancer Res. 55:1441-1443.
  • O'Keefe D.S., et al.,(1998), Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.Biochim. Biophys. Acta 1443:113-127.
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