Mannan Binding Lectin/MBL2 Protein, Human, Recombinant

1/1
Price:
Size:
Number:

Mannan Binding Lectin/MBL2 Protein, Human, Recombinant: 製品情報

純度
> 95 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
活性
Testing in progress
タンパク質の構築
A DNA sequence encoding the human MBL (NP_000233.1) (Met1-Ile 248) was expressed.
NP No.
発現ホスト
CHO Stable Cells
Human
予測N末端
Glu 21
分子量
The recombinant human MBL consists of 228 amino acids and predicts a molecular mass of 24 KDa. It migrates as an approximately 31 KDa band in SDS-PAGE under reducing conditions.
バッファー
Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Mannan Binding Lectin/MBL2 Protein, Human, Recombinant: 画像

Mannan Binding Lectin/MBL2 Protein, Human, Recombinant: 別名

COLEC1 Protein, Human; HSMBPC Protein, Human; MBL Protein, Human; MBL2D Protein, Human; MBP Protein, Human; MBP-C Protein, Human; MBP1 Protein, Human; MBPD Protein, Human

Mannan Binding Lectin/MBL2 背景情報

MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.
完全な名称
mannose-binding lectin (protein C) 2, soluble
参考文献
  • Garred P, et al. (2006) Mannose-binding lectin and its genetic variants. Genes Immun. 7(2): 85-94.
  • Brown KS, et al. (2007) Mannan binding lectin and viral hepatitis. Immunol Lett. 108(1): 34-44.
  • Garred P. (2008) Mannose-binding lectin genetics: from A to Z. Biochem Soc Trans. 36(Pt 6): 1461-6.
  • Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.
  • Muller YL, et al. (2010) Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish. Diabetes. 59(8): 2080-5.
  • Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro
    Author
    Guo, J;Cao, Y;Qin, K;Zhao, X;Wang, D;Li, Z;Xin, L;Shu, Y;Zhou, J;
    Year
    2015
    Journal
    Biochem. Biophys. Res. Commun.
    Application
    binding
  • Broad spectrum capture of clinical pathogens using engineered Fc-Mannose-Binding Lectin (FcMBL) enhanced by antibiotic treatment
    Author
    Seiler, B;Cartwright, M;Dinis, A;Duffy, S;Lombardo, P;Cartwright, D;Super, E;Lanzaro, J;Dugas, K;Super, M;Ingber, D;
    Year
    2018
    Journal
    bioRxiv
    Application
    binding
  • Modified Clinical Monitoring Assessment Criteria for Multi-Organ Failure during Bacteremia and Sepsis Progression in a Pig Model
    Author
    Waterhouse, A;Leslie, DC;Bolgen, DE;Lightbown, S;Dimitrakakis, N;Cartwright, MJ;Seiler, B;Lightbown, K;Smith, K;Lombardo, P;Hicks-Berthet, JB;Jurek, S;Donovan, K;Super, M;Ingber, AP;
    Year
    2018
    Journal
    Advances in Critical Care Medicine
    Application
    binding
カートに追加しました カートに追加しませんでした カートを更新しています。少々お待ちください