Mannan Binding Lectin/MBL2 Protein, Human, Recombinant

Mannan Binding Lectin/MBL2 Protein, Human, Recombinant: 製品情報

> 95 % as determined by SDS-PAGE
< 1.0 EU per μg of the protein as determined by the LAL method
Testing in progress
A DNA sequence encoding the human MBL (NP_000233.1) (Met1-Ile 248) was expressed.
NP No.
CHO Stable Cells
Glu 21
The recombinant human MBL consists of 228 amino acids and predicts a molecular mass of 24 KDa. It migrates as an approximately 31 KDa band in SDS-PAGE under reducing conditions.
Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Mannan Binding Lectin/MBL2 Protein, Human, Recombinant: 画像

Mannan Binding Lectin/MBL2 Protein, Human, Recombinant: 別名

COLEC1 Protein, Human; HSMBPC Protein, Human; MBL Protein, Human; MBL2D Protein, Human; MBP Protein, Human; MBP-C Protein, Human; MBP1 Protein, Human; MBPD Protein, Human

Mannan Binding Lectin/MBL2 背景情報

MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defense. They bind sugar structures or acetylated compounds present on microorganisms and dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in the development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in the promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and the oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcomes for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.
mannose-binding lectin (protein C) 2, soluble
Related Pathways
  • Complement Activation Pathways
    Complement Activation Pathways
  • Garred P, et al. (2006) Mannose-binding lectin and its genetic variants. Genes Immun. 7(2): 85-94.
  • Brown KS, et al. (2007) Mannan binding lectin and viral hepatitis. Immunol Lett. 108(1): 34-44.
  • Garred P. (2008) Mannose-binding lectin genetics: from A to Z. Biochem Soc Trans. 36(Pt 6): 1461-6.
  • Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.
  • Muller YL, et al. (2010) Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish. Diabetes. 59(8): 2080-5.
  • Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro
    Guo, J;Cao, Y;Qin, K;Zhao, X;Wang, D;Li, Z;Xin, L;Shu, Y;Zhou, J;
    Biochem. Biophys. Res. Commun.
  • Broad spectrum capture of clinical pathogens using engineered Fc-Mannose-Binding Lectin (FcMBL) enhanced by antibiotic treatment
    Seiler, B;Cartwright, M;Dinis, A;Duffy, S;Lombardo, P;Cartwright, D;Super, E;Lanzaro, J;Dugas, K;Super, M;Ingber, D;
  • Modified Clinical Monitoring Assessment Criteria for Multi-Organ Failure during Bacteremia and Sepsis Progression in a Pig Model
    Waterhouse, A;Leslie, DC;Bolgen, DE;Lightbown, S;Dimitrakakis, N;Cartwright, MJ;Seiler, B;Lightbown, K;Smith, K;Lombardo, P;Hicks-Berthet, JB;Jurek, S;Donovan, K;Super, M;Ingber, AP;
    Advances in Critical Care Medicine
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