IL-33 Protein, Human, Recombinant

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IL-33 Protein, Human, Recombinant: 製品情報

純度
> 98 % as determined by SDS-PAGE
内毒素
Please contact us for more information.
活性
Measured by its binding ability in a functional ELISA. Immobilized human IL-33 at 10 μg/ml (100 μl/well) can bind human IL1RL1 with a linear range of 0.31-5 ng/ml.
タンパク質の構築
A DNA sequence encoding the C-terminal segment of human IL33 (NP_254274.1) (Ser 112-Thr 270) was expressed with an initial Met at the N-terminus.
NP No.
発現ホスト
E. coli
Human
予測N末端
Met
分子量
The recombinant human IL33 comprises 160 amino acids and predicts a molecular mass of 18 kDa as estimated in SDS-PAGE under reducing conditions.
バッファー
Lyophilized from sterile PBS, pH 7.4
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL-33 Protein, Human, Recombinant: 画像

Measured by its binding ability in a functional ELISA. Immobilized human IL-33 at 10 μg/ml (100 μl/well) can bind human IL1RL1 with a linear range of 0.31-5 ng/ml.

IL-33 Protein, Human, Recombinant: 別名

C9orf26 Protein, Human; DVS27 Protein, Human; IL1F11 Protein, Human; NF-HEV Protein, Human; NFEHEV Protein, Human

IL-33 背景情報

Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial enules), is a proinflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 protein is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyers's patches, and lymph nodes. IL-33 protein has transcriptional regulatory properties, and the researches suggested that IL-33 is a dual-function protein that might act both as a cytokine and as an intracellular nuclear factor. As a type 2 cytokines, IL-33 protein also play a pivotal role in helminthic infection and allergic disorders.
完全な名称
interleukin 33
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
参考文献
  • Iikura M, et al. (2007) IL-33 can promote survival, adhesion and cytokine production in human mast cells. Lab Invest. 87(10): 971-8.
  • Lamkanfi M, et al. (2009) IL-33 raises alarm. Immunity. 31(1): 5-7.
  • Altered serum levels of IL-33 in patients with advanced systolic chronic heart failure: correlation with oxidative stress
    Author
    Zhang, HF;Xie, SL;Chen, YX;Mai, JT;Wang, JF;Zhu, WL;Zhu, LG;
    Year
    2012
    Journal
    J Transl Med
    Application
    cell-based (culture)
  • IL-33 signaling fuels outgrowth and metastasis of human lung cancer
    Author
    Wang, C;Chen, Z;Bu, X;Han, Y;Shan, S;Ren, T;Song, W;
    Year
    2016
    Journal
    Biochem. Biophys. Res. Commun.
    Application
    cell-based
  • Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis
    Author
    Lei, H;Li, X;Jing, B;Xu, H;Wu, Y;
    Year
    2017
    Journal
    PLoS ONE
    Application
    cell-based
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